Aptagen, LLC
Aptamer Glu3 against Glucosepane (ID# 9647)
DNA
Glucosepane
Protein
17.10 nM (reported value)
(100 mM NaCl, 20 mM Tris-HCl, 2 mM MgCl2, 5 mM KCl, 1 mM CaCl2, 0.02% (v/v) Tween 20, pH 7.6)
25°C
heated to 95 °C for 5 min, immediately cooled, and kept at 4 °C for 5 min, followed by incubation at 25 °C for 20 min
N/A
Glu3 showed robust and specific fluorescence labeling of glucosepane in skin sections from diabetic db/db mice, clearly distinguishing them from healthy wild-type tissues, whereas Glu4 and the negative control ATCG44 exhibited no labeling.
5'-dTpdApdGpdGpdGpdApdApdGpdApdGpdApdApdGpdGpdApdCpdApdTpdApdTpdGpdApdTpdGpdCpdGpdCpdGpdCpdApdGpdApdTpdTpdApdApdCpdCpdCpdCpdCpdCpdApdApdTpdGpdCpdTpdGpdCpdApdCpdCpdGpdApdGpdCpdCpdApdCpdGpdApdTpdTpdTpdGpdApdCpdTpdApdGpdTpdApdCpdApdTpdGpdApdCpdCpdApdCpdTpdTpdGpdAp-3'
86
26537.2 g/mole
846200 L/(mole·cm)
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Li, Runliu & Draphoen, Bastian & Lindén, Mika & Singh, Karmveer & scharffetter-kochanek, Karin & Stürmer, Andreas & Rosenau, Frank & Kissmann, Ann-Kathrin. (2025). FluMag-SELEX derived specific individual aptamers can fluorescently label the ageing immanent protein-crosslinker glucosepane in diabetic mouse tissues. Nanoscale horizons. 10. 10.1039/d5nh00263j.
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