Aptamer Details

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Amyloid Peptide BetaA4(1ƒ?? 40) (B55) (ID# 7485)

Aptamer Chemistry: RNA

Target: Amyloid Peptide BetaA4(1ƒ?? 40)

Antigen/Target Category: Peptide

Affinity (Kd): 29 nM (reported value)

Binding Conditions/Buffer: Binding Buffer (10 mM Trisƒ??HCl (pH 7.5), 150 mM NaCl, 5 mM MgCl2, 1 mM EDTA). Incubated at room temperature.

Binding Temp: N/A°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Comments: This aptamer is specific to polymeric amyloid.

Sequence ():

Length: 107

Molecular Weight: 34199.41

Extinction Coefficient: 1012800

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Ylera, Francisco, et al. "Selection of RNA Aptamers to the Alzheimer's Disease Amyloid Peptide." Biochemical and Biophysical Research Communities, 290 (2002): 1583-1588.

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