Aptamer Details

Back to Search Results

A1 (ID# 9535)

Aptamer Chemistry: DNA

Target: BACE1

Antigen/Target Category: Small Organic

Affinity (Kd): 68.5655 ± 8.1237 nM (reported value)

Binding Temp: 80.6°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Sequence ():

Length: 73

Molecular Weight: 22541.6 g/mole

Extinction Coefficient: 698200 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Liang H, Shi Y, Kou Z, Peng Y, Chen W, Li X, Li S, Wang Y, Wang F, Zhang X. Inhibition of BACE1 Activity by a DNA Aptamer in an Alzheimer's Disease Cell Model. PLoS One. 2015 Oct 16;10(10):e0140733. doi: 10.1371/journal.pone.0140733. PMID: 26473367; PMCID: PMC4608735.

Have your aptamer oligo synthesized ORDER