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Apta-Index™: Gonadotropin-releasing hormone 1 (60-mer S42) (ID# 78)

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Gonadotropin-releasing hormone 1 (60-mer S42) (ID# 78)

Gonadotropin-releasing hormone 1 (60-mer S42)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
L-DNA Gonadoliberin/Gonadotropin-releasing hormone 1 (GnRH) Peptide 45 nM (reported value) Selection Buffer: 10 mM HEPES (pH 7.5), 137 mM NaCl, 2.7 mM KCl, 2 mM CaCl22, 1 mM MgCl2, 0.005% Triton X-100 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Reduced Ca2+ release in Chinese hamster ovary cells transfected with human GnRH receptor with an IC50 value of 50 nM.
5'-LdGLdCLdGLdGLdCLdGLdGLdALdGLdGLdGLdTLdGLdGLdGLdCLdTLdGLdGLdGLdGLdCLdTLdGLdGLdGLdCLdCLdGLdGLdGLdGLdGLdGLdCLdGLdTLdGLdCLdGLdTLdALdALdGLdCLdALdCLdGLdTLdALdGLdCLdCLdTLdCLdGLdCLdCLdGLdC-3'
60 48667.48 g/mole 555200.00 L/(mole·cm) 80.00% 1.80 87.66

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Leva, S., et al. "GnRH Binding RNA and DNA Spiegelmers: A Novel Approach toward GnRH Antagonism." Chemistry and Biology, 9 (2002): 351-359.

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