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Apta-Index™: Tumour Marker MUC1 (S1.6) (ID# 76)

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Tumour Marker MUC1 (S1.6) (ID# 76)

Tumour Marker MUC1 (S1.6)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Tumour Marker MUC Peptide 0.2131 nM (reported value) Binding Buffer (0.2 M NaHCO3 and 0.5 M NaCl (pH 7.4)) N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Kd values given in Table 2 of reference article may have been miscalculated. Using the kd and ka given in Table 2 of the reference, we have calculated the above Kd value from Kd=(kd/ka).
5'-dGpdGpdGpdApdGpdApdCpdApdApdGpdApdApdTpdApdApdApdCpdGpdCpdTpdCpdApdAp dGpdCpdApdApdCpdApdGpdGpdGpdTpdApdTpdCpdCpdApdApdApdGpdGpdApdTpdCpdApdApdApdTpdTpdCpdGpdApdCpdApdGpdGpdApdGpdGpdCpdTpdCpdApdCpdApdApdCpdApdGpdGpdCp-3'
72 22336.60 g/mole 737600.00 L/(mole·cm) 48.61% 1.36 30.28

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Ferreira, C., et al. "DNA Aptamers That Bi nd to MUC1 Tumour Marker: Design and Characterization of MUC1-Binding Single-Stranded DNA Aptamers." Tumor Biology, 27(2006): 289–301.

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