Aptagen, LLC
DNA
Tumour Marker MUC
Peptide
0.2131 nM (reported value)
Binding Buffer (0.2 M NaHCO3 and 0.5 M NaCl (pH 7.4))
N/A°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Kd values given in Table 2 of reference article may have been miscalculated. Using the kd and ka given in Table 2 of the reference, we have calculated the above Kd value from Kd=(kd/ka).
Tumour Marker MUC1 (S1.6) (ID# 76)
5'dGpdGpdGpdApdGpdApdCpdApdApdGpdApdApdTpdApdApdApdCpdGpdCpdTpdCpdApdAp dGpdCpdApdApdCpdApdGpdGpdGpdTpdApdTpdCpdCpdApdApdApdGpdGpdApdTpdCpdApdApdApdTpdTpdCpdGpdApdCpdApdGpdGpdApdGpdGpdCpdTpdCpdApdCpdApdApdCpdApdGpdGpdCp3'
72
22336.6 g/mole
737600 L/(mole·cm)
48.61%
1.36
30.28
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Ferreira, C., et al. "DNA Aptamers That Bi nd to MUC1 Tumour Marker: Design and Characterization of MUC1-Binding Single-Stranded DNA Aptamers." Tumor Biology, 27(2006): 289ƒ??301.
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