Aptamer Details

Interleukin 8 (8A-35) (ID# 618)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.

Aptamer Chemistry: 2'-F-RNA Target: Interleukin-8 (CXCL-8) Antigen/Target Category: Protein Affinity (Kd): 1.72 pM (reported value) Binding Conditions/Buffer: 30 mM Tris-HCl (pH 7.5), 150 mM NaCl, 1.5 mM MgCl2, 2mM DTT, and 1% BSA Binding Temp: 23°C Refolding Protocol: N/A Specificity: Counter Targets: CXCL-1 and CXCL-2 Comments: IL-8

Sequence (): 5'rGprGprGprGprGpfCpfUpfUprApfUpfCprApfUpfUpfCpfCprApfUpfUpfUprAprGpfUprGpfUpfUprApfUprGprApfUprAprApfCpfCp3' Length: 35 Molecular Weight: 11182.56 g/mole Extinction Coefficient: 353800 L/(mole·cm) GC Content: 40.00% nmoles/OD₂₆₀: 2.83 μg/OD₂₆₀: 31.61

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Sung HJ, Choi S, Lee JW, Ok CY, Bae YS, Kim YH, Lee W, Heo K, Kim IH. Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8. Biomaterials. 2014 Jan;35(1):578-89. doi: 10.1016/j.biomaterials.2013.09.107. Epub 2013 Oct 13.

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Aptamer Details

Interleukin 8 (8A-35) (ID# 618)

Sung HJ, Choi S, Lee JW, Ok CY, Bae YS, Kim YH, Lee W, Heo K, Kim IH. Inhibition of human neutrophil activity by an RNA aptamer bound to interleukin-8. Biomaterials. 2014 Jan;35(1):578-89. doi: 10.1016/j.biomaterials.2013.09.107. Epub 2013 Oct 13.

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