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Apta-Index™: IR-A48 (ID# 605)

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IR-A48 (ID# 605)

IR-A48
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Insulin Receptor Protein 3.5 nM (reported value) Krebs-Ringer HEPES Buffer. Tested in vivo. 95 C for 5 minutes, allowed to cool to room temperature. The 'N's in the structure indicate 5-[N-(1-naphthylmethyl)carboxamide]-2-deoxyuridine (Nap-dU) used in place of Thymine to improve binding efficiency.
5'-dCpdGpdCpdCpdTpdGpdGpdNpdGpdNpdNpdApdApdGpdApdCpdApdApdCpdCpdNpdCpdNpdApdGpdGpdNpdCpdApdGpdGpdCpdGp-3'
33 10129.43 g/mole 313200.00 L/(mole·cm) 70.37% 3.19 32.34

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Yunn N, Koh A, Han S, Lim JH, Park S, et al. (2015) Agonistic Aptamer to the Insulin Receptor Leads to Biased Signaling and Functional Selectivity Through Allosteric Modulation. Nucleic Acids Research 1. doi:10.1093/narlgkv767

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