Aptamer Details

A09 (ID# 568)

Aptamer Chemistry: RNA Target: Penetrating the Blood Brain Barrier (BBB) Antigen/Target Category: Other Affinity (Kd): nM (reported value) Binding Conditions/Buffer: 10mM HEPES, pH 7.4, 50mM NaCl, 1mM MgCl2, 1mM CaCl2, 0.01% BSA Binding Temp: 37°C Refolding Protocol: Denature at 94C for 3 minutes, and then slowly refold at room temperature Comments:

Sequence (): Length: 180 Molecular Weight: 17891.96 g/mole Extinction Coefficient: 521300 L/(mole·cm) GC Content: 78.18% nmoles/OD₂₆₀: 1.92 μg/OD₂₆₀: 34.32

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Congsheng Cheng, Yong Hong Chen, Kim A Lennox, Mark A Behlke, Beverly L Davidson, "In vivo SELEX for Identification of Brain-penetrating Aptamers" Molecular Therapy-Nucleic Acids (2013)2, e67, American Society of Gene & Cell Therapy

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Aptamer Details

A09 (ID# 568)

Congsheng Cheng, Yong Hong Chen, Kim A Lennox, Mark A Behlke, Beverly L Davidson, "In vivo SELEX for Identification of Brain-penetrating Aptamers" Molecular Therapy-Nucleic Acids (2013)2, e67, American Society of Gene & Cell Therapy

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