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Apta-Index™: Anti Influenza NS1 protein (ID# 504)

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Anti Influenza NS1 protein (ID# 504)

Anti Influenza NS1 protein
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA NS1 Protein 19.91 nM (reported value) 50 mM Tris/Cl (pH 8.0), 150 mM NaCl, 1.5 mM MgCl2, 2 mM DTT and 1% (w/v) BSA 95C for 10min Denaturing Cold-shock by placing on ice for 10min to renature “NS1 is a multifunctional protein…However, the major role of NS1 is to Antagonize Interferons…inhibiting the host’s Innate immunity” (Woo) This aptamer has shown activity that blocks NS1 interaction with hosts (woo)
5'-dGpdCpdApdApdTpdGpdGpdTpdApdCpdGpdGpdTpdApdCpdTpdTpdCpdCpdGpdCpdGpdGpdTpdCpdCpdGpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdTpdGpdGpdGpdGpdGpdGpdTpdGpdCpdGpdGpdGpdGpdGpdGpdGpdCpdGpdGpdCpdCpdGpdCpdApdApdApdApdGpdTpdGpdCpdApdCpdGpdCpdTpdApdCpdTpdTpdTpdGpdCpdTpdApdAp-3'
88 27570.81 g/mole 834900.00 L/(mole·cm) 67.05% 1.20 33.02

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Hye-Min Woo. Single-stranded DNA aptamer that specifically binds to the influenza Virus NS1 protein suppresses interferon antagonism

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