Aptagen, LLC
DNA
NS1
Protein
19.91 nM (reported value)
50 mM Tris/Cl (pH 8.0), 150 mM NaCl, 1.5 mM MgCl2, 2 mM DTT and 1% (w/v) BSA
23°C
95C for 10min Denaturing Cold-shock by placing on ice for 10min to renature
ƒ??NS1 is a multifunctional proteinƒ??However, the major role of NS1 is to Antagonize Interferonsƒ??inhibiting the hostƒ??s Innate immunityƒ? (Woo) This aptamer has shown activity that blocks NS1 interaction with hosts (woo)
Anti Influenza NS1 protein (ID# 504)
5'dGpdCpdApdApdTpdGpdGpdTpdApdCpdGpdGpdTpdApdCpdTpdTpdCpdCpdGpdCpdGpdGpdTpdCpdCpdGpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdGpdTpdGpdGpdTpdGpdGpdGpdGpdGpdGpdTpdGpdCpdGpdGpdGpdGpdGpdGpdGpdCpdGpdGpdCpdCpdGpdCpdApdApdApdApdGpdTpdGpdCpdApdCpdGpdCpdTpdApdCpdTpdTpdTpdGpdCpdTpdApdAp3'
88
27570.81 g/mole
834900 L/(mole·cm)
67.05%
1.20
33.02
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Hye-Min Woo. Single-stranded DNA aptamer that specifically binds to the influenza Virus NS1 protein suppresses interferon antagonism
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