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Apta-Index™: Leptin (Lep3) (ID# 500)

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Leptin (Lep3) (ID# 500)

Leptin (Lep3)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Leptin Protein 0.32 µM (reported value) TGK 1X: 25 mM Tris, 192 mM glycine, and 5 mM potassium phosphate (pH 8.3) Heated to 94°C and cooled at a rate of 0.5°C/s to 20°C. This aptamer was selected using nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM). Binding affinity against immobilized leptin was much lower (1.50 μM).
5'- dCpdTpdTpdCpdTpdGpdCpdCpdCpdGp dCpdCpdTpdCpdCpdTpdTpdCpdCpdGp dTpdTpdApdApdTpdGpdGpdGpdGpdGp dApdTpdCpdTpdCpdGpdCpdGpdGpdCp dCpdGpdTpdTpdCpdTpdTpdGpdTpdTp dGpdCpdTpdTpdApdTpdApdCpdApdGp dGpdApdGpdApdCpdGpdApdGpdApdTp dApdGpdGpdCpdGpdGpdApdCpdApdCp dTp-3'
81 24925.14 g/mole 744800.00 L/(mole·cm) 56.79% 1.34 33.47

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Ashley J and Li S FY. (2013) Three-dimensional selection of leptin aptamers using capillary electrophoresis and implications for clone validation. Anal Biochem. 434: 146-152.

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