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Apta-Index™: Tumor Endothelial Cells (AraHH001) (ID# 492)

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Tumor Endothelial Cells (AraHH001) (ID# 492)

Tumor Endothelial Cells (AraHH001)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Mouse and Human Tumour Endothelial Cells (mTECs and hTECs) Cells 43.8 nM (reported value) Selection Buffer: 50 mM Tris-HCl (pH 7.5), 5 mM KCl, 100 mM NaCl, 1 mM MgCl2, 250 mM sucrose and 0.1% sodium azide. Heated at 80°C for 10 min, then slowly cooled. Additional testing by Ara et al. revealed AraHH001 impaired the ability of mTECs to form capillary-like structures in a matrigel. Also, confocal microscopy showed that AraHH001 is internalized by the cell into acid compartments.
40 12071.86 g/mole 364700.00 L/(mole·cm) 52.50% 2.74 33.10

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Ara N, Hyodo M, Ohga N, Hida, N, Harishima H. (2012) Development of a novel DNA aptamer ligand targeting to primary cultured tumor endothelial cells by a cell-based SELEX method. PLOS one 7: e50174.

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