Aptamer Details

Anterior Gradient Homolog 2 (C14B0) (ID# 478)

Aptamer Chemistry: DNA Target: Anterior Gradient Homolog 2 (AGR2) Antigen/Target Category: Protein Affinity (Kd): 8.5 nM (reported value) Binding Conditions/Buffer: Binding Buffer: PBS with 137 mM NACl, 2.7 mM KCl, 10 mM NaHPO₄, and 2.0 mM KH₂PO₄ Binding Temp: N/A°C Refolding Protocol: Denatured at 95° C for 5 minutes, subsequently cooled on ice for 10 minutes. Then incubated at RT for 10 minutes. Comments: Aptamer is expected to form a G-quartet.

Sequence (): 5'dTpdCpdTpdCpdGpdGpdApdCpdGpdCpdGpdTpdGpdTpdGpdGpdTpdCpdGpdGpdCpdGpdGpdGpdTpdGpdGpdGpdApdGpdTpdTpdGpdTpdGpdGpdGpdGpdGpdGpdGpdGpdGpdTpdGpdGpdGpdApdGpdGpdGpdTpdTpdCpdTpdTpdTpdGpdTpdTpdTpdGpdApdTpdCpdTpdTpdTpdCpdTpdCpdGpdCpdTpdGpdCpdCpdTpdGpdGpdCpdCpdCpdTpdApdGpdApdGpdTpdGpdTpdCpdGpdCpdTpdGpdCpdCpdTpdGpdGpdCpdApdGpdApdGpdTpdGp3' Length: 108 Molecular Weight: 33748.78 g/mole Extinction Coefficient: 995300 L/(mole·cm) GC Content: 63.89% nmoles/OD₂₆₀: 1.00 μg/OD₂₆₀: 33.91

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Wu et al. "Identification, Characterization and Amplification of a G-Quadruplex Structured DNA Aptamer Against Cancer Biomarker Protein Anterior Gradient Homolog 2." PLOS, 9 (2012):e46393.

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Aptamer Details

Anterior Gradient Homolog 2 (C14B0) (ID# 478)

Wu et al. "Identification, Characterization and Amplification of a G-Quadruplex Structured DNA Aptamer Against Cancer Biomarker Protein Anterior Gradient Homolog 2." PLOS, 9 (2012):e46393.

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