Aptagen, LLC
RNA
Cells presenting IL-6R
Cells
8.5 nM (reported value)
Selection Buffer (used for Filter Retention Assay): 137 mM NaCl, 2.7 mM KCl, 6.5 mM Na2HPO4, and 3 mM MgCl2 at PH 7.5.
37°C
None Listed
No binding to IL-6 or lysozyme observed.
Forms a G-quartet structure.
This aptamer is a truncated version of AIR-3 and binds to IL-6r presenting cells. It is then internalized and was used by Meyer et al. do deliver fluorescently labeled strptavidin.
Interleukin-6 receptor (AIR-3A) (ID# 474)
This aptamer is a truncated version of AIR-3 and binds to IL-6r presenting cells. It is then internalized and was used by Meyer et al. do deliver fluorescently labeled strptavidin.
5'rGprGprGprGprAprGprGprCprUprGprUprGprGprUprGprAprGprGprGp3'
19
6307.88 g/mole
193400 L/(mole·cm)
73.68%
5.17
32.62
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Meyer C, U Hahn, et al. (2012) Interleukin-6 Receptor specific RNA aptamers for cargo delivery into target cells. RNA Biol
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