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Apta-Index™: ß-Catenin (ID# 468)

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ß-Catenin (ID# 468)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA Arm 1-12 of B-catenin Protein 5 nM (reported value) Binding buffer: 25 mM HEPES (pH 7.5), 150 mM NaCl, 1 mM MgCl2, 2 mM DTT, and 40 U RNase inhibitor. N/A Expression of this aptamer in cells using the U6 promoter produced nuclear-localized aptamers that bound to ß-catenin, inhibited transcription of cyclin D1 and c-myc, and prevented alternative splicing.
5'-rGprGprAp rCprGprCp rGprUprGp rGprUprAp rCprCprAp rGprGprCp rCprGprAp rUprCprUp rAprUprGp rGprAprCp rGprCprUp rAprUprAp rGprGprCp rAprCprAp rCprCprGp rGprAprUp rAprCprUp rUprUprAp rAprCprGp rAprUprUp rGprGprCp rUprAprAp rGprCprUp rUprCprCp rGprCprGp rGprGprGp rAprUprCp-3'
81 26107.74 g/mole 792100.00 L/(mole·cm) 56.79% 1.26 32.96

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Lee HK, Choi YS, Park YA, et al. (2006) Modulation of oncogenic transcription and alternative splicing by beta-catenin and an RNA aptamer in colon cancer cells.

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