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Apta-Index™: HIV co-receptor CCR5 (BY6M4) (ID# 461)

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HIV co-receptor CCR5 (BY6M4) (ID# 461)

HIV co-receptor CCR5 (BY6M4)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Peptide CCR5 Protein N/A nM (reported value) RPMI-10 medium N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Decreased induction of R5-tropic reporter virus by 95%. Did not affect CD4 or CXCR4 expression.
5'-MetAlaTyrProTyrAspValProAspTyrAlaAspLeuProAsnLeuTrpPheIleIleIlePheLeuArgLeuValValLeuPheLeuLeuPheValIleValLeuIleArgAlaSerValLeuTyrTrp-3'
44 6018.13 g/mole

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Scheideman EH, DiMaio D, et al. (2012) Transmembrane protein aptamers that inhibit CCR5 expression and HIV coreceptor function. J. Virol. 86: 10281-10292.

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