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Apta-Index™: Thrombin (15mer-29-mer dimer with 20T linker) (ID# 447)

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Thrombin (15mer-29-mer dimer with 20T linker) (ID# 447)

Thrombin (15mer-29-mer dimer with 20T linker)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Thrombin Protein 0.35 nM (reported value) Binding Buffer: 50 mM Tris-HCl, 300 mM NaCl, 5 mM KCl, pH 8.0. N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. This aptamer is a dimerized version of the 15-mer and 29-mer thrombin aptamers connected by a 20-mer thymidine linker. This aptamer showed improved affinity and inhibitory effects to the monomer components.
5'-dGpdGpdTp dTpdGpdGp dTpdGpdTp dGpdGpdTp dTpdGpdGp dTpdTpdTpdTpdTp dTpdTpdTpdTpdTp dTpdTpdTpdTpdTp dTpdTpdTpdTpdTp dApdGpdTp dCpdCpdGp dTpdGpdGp dTpdApdGp dGpdGpdCp dApdGpdGp dTpdTpdGp dGpdGpdGp dTpdGpdAp dCpdTp-3'
64 19958.03 g/mole 588600.00 L/(mole·cm) 42.19% 1.70 33.91

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

H. Hasegawa et al. Improvement of aptamer affinity by dimerization. Sensors 8(2008): 1090-1098.

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