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Apta-Index™: EGFR (CL4) (ID# 446)

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EGFR (CL4) (ID# 446)

EGFR (CL4)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA EGFR - Extracellular Domain Protein 10 nM (reported value) Buffer used for Binding Assays: PBS with 0.01% BSA. Incubation Time: 15 minutes. 85°C for 5 minutes in DMEM serum free, snap-cooled on ice for 2 minutes, gradual warming to 37°C (from article reference [34]) This apatamer was shown to induce apoptosis in A549 cells and inhibit tumor growth in human non-small-cell lung cancer xenograft mice.
5'-rGpfCpfCpfUpfUprAprGpfUprAprApfCprGpfUprGpfCpfUpfUpfUprGprApfUprGpfUpfCprGprApfUpfUpfCprGprApfCprAprGprGprAprGprGpfCp-3'
39 12561.44 g/mole 386200.00 L/(mole·cm) 51.28% 2.59 32.53

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

CL Esposito et al. A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death. PLoS One 6(2011):e24071.

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