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Apta-Index™: Heparanase (3M NaSCN) (ID# 424)

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Heparanase (3M NaSCN) (ID# 424)

Heparanase (3M NaSCN)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Heparanase (HPSE1) Protein 13 nM (reported value) Salt Solution: 100 mM NaCl, 20 mM KCl, 5 mM MgCl2 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Selected in the presence of 3.0 M NaSCN.
No inhibitory effect on heparanase activity was observed.
5'- dGpdGpdGpdApdGpdApdCpdApdApdGp dApdApdTpdApdApdApdCpdGpdCpdTp dCpdApdApdTpdTpdTpdApdApdCpdGp dTpdApdTpdTpdTpdApdTpdTpdCpdAp dApdGpdCpdTpdCpdGpdTpdApdTpdTp dCpdGpdApdCpdApdGpdGpdApdGpdGp dCpdTpdCpdApdCpdApdApdCpdApdGp dGpdCp-3'
72 22240.55 g/mole 719300.00 L/(mole·cm) 43.06% 1.39 30.92

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Simmons, SC, et al. Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1). PLoS One (2012) 7:e37938.

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