Aptagen, LLC
DNA
Heparanase (HPSE1)
Protein
13 nM (reported value)
Salt Solution: 100 mM NaCl, 20 mM KCl, 5 mM MgCl2
RT°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Selected in the presence of 3.0 M NaSCN.
No inhibitory effect on heparanase activity was observed.
Heparanase (3M NaSCN) (ID# 424)
No inhibitory effect on heparanase activity was observed.
5' dGpdGpdGpdApdGpdApdCpdApdApdGp dApdApdTpdApdApdApdCpdGpdCpdTp dCpdApdApdTpdTpdTpdApdApdCpdGp dTpdApdTpdTpdTpdApdTpdTpdCpdAp dApdGpdCpdTpdCpdGpdTpdApdTpdTp dCpdGpdApdCpdApdGpdGpdApdGpdGp dCpdTpdCpdApdCpdApdApdCpdApdGp dGpdCp3'
74
22240.55 g/mole
719300 L/(mole·cm)
43.06%
1.39
30.92
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Simmons, SC, et al. Development of novel single-stranded nucleic acid aptamers against the pro-angiogenic and metastatic enzyme heparanase (HPSE1). PLoS One (2012) 7:e37938.
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