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Apta-Index™: Cocaine (MNS-4.1) (ID# 418)

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Cocaine (MNS-4.1) (ID# 418)

Cocaine (MNS-4.1)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Cocaine Small Organic 0.4 µM (reported value) Phosphate buffer: 20 mM, pH7, 200 mM NaCl. N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. This aptamer is predicted to form a three-way junction in the presence of cocaine.
5'-dGpdGpdGpdApdGpdApdCpdApdApdGpdGpdApdApdApdApdTpdCpdCpdTpdTpdCpdApdApdTpdGpdApdApdGpdTpdGpdGpdGpdTpdCpdGpdApdCpdAp-3'
38 11833.78 g/mole 392900.00 L/(mole·cm) 47.37% 2.55 30.12

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

M Stojanovic, P de Prada, and D Landry. Aptamer-based folding fluorescent sensor for cocaine. J. Am. Chem. Soc. 123(2001): 4928-4931.

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