Aptagen, LLC
DNA
Cocaine
Small Organic
0.4 µM (reported value)
Phosphate buffer: 20 mM, pH7, 200 mM NaCl.
RT°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Did not bind to metabolites benzoyl ecgonine or ecgonine methyl ester.
This aptamer is predicted to form a three-way junction in the presence of cocaine.
Cocaine (MNS-4.1) (ID# 418)
5'dGpdGpdGpdApdGpdApdCpdApdApdGpdGpdApdApdApdApdTpdCpdCpdTpdTpdCpdApdApdTpdGpdApdApdGpdTpdGpdGpdGpdTpdCpdGpdApdCpdAp3'
38
11833.78 g/mole
392900 L/(mole·cm)
47.37%
2.55
30.12
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
M Stojanovic, P de Prada, and D Landry. Aptamer-based folding fluorescent sensor for cocaine. J. Am. Chem. Soc. 123(2001): 4928-4931.
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