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Apta-Index™: Gastrin-Releasing Peptide (GRP-1) (ID# 386)

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Gastrin-Releasing Peptide (GRP-1) (ID# 386)

Gastrin-Releasing Peptide (GRP-1)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Peptide Gastrin-Releasing Peptide Receptor (GRPR) aka BB2 Receptor) Protein N/A nM (reported value) Peptide binding assays: Phosphate-buffered saline (PBS) with 1% fetal calf serum (FCS). N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Aptamer was conjugated to survivin siRNA through the terminal cysteine residue, which was successfully delivered to MDA-MB 231 cells.
CysGlyGlyAsnHisTrpAlaValGlyHisLeuMet
12 1417.70 g/mole

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

M Sioud et al. Efficient siRNA targeted delivery into cancer cells by gastrin-releasing peptides. Bioconjugate Chem 23(2012): 1040-1049.

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