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Apta-Index™: HER-2 (HB5) (ID# 380)

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HER-2 (HB5) (ID# 380)

HER-2 (HB5)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA HER2 epitope peptide (INCTHSCVDLDDKGCPAEQR) Protein 18.9 nM (reported value) Hanks buffer with 0.1 mg/mL salmon sperm DNA and 1 mg/mL of BSA Heat to 95°C for 5?min and then cool immediately on ice for 15?min. Aptamer was complexed with doxorubicin and selectively delivered doxorubicin to HER2-positive cells in vitro. Affinity to the HER2 extracellular domain is 316 nM.
5'- dApdApdCpdCpdGpdCpdCpdCpdApdAp dApdTpdCpdCpdCpdTpdApdApdGpdAp dGpdTpdCpdTpdGpdCpdApdCpdTpdTp dGpdTpdCpdApdTpdTpdTpdTpdGpdTp dApdTpdApdTpdGpdTpdApdTpdTpdTp dGpdGpdTpdTpdTpdTpdTpdGpdGpdCp dTpdCpdTpdCpdApdCpdApdGpdApdCp dApdCpdApdCpdTpdApdCpdApdCpdAp dCpdGpdCpdApdCpdAp-3'
86 26271.12 g/mole 811300.00 L/(mole·cm) 43.02% 1.23 32.38

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Z Liu et al. Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro. J Transl Med 10(2012): 148-157.

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