Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
Human matrix metalloprotease 9 (hMMP-9)
Protein
8.1 nM (reported value)
SP buffer: 50 mM Tris HCl, pH 7.4, 50 mM NaCl, 100 mM KCl, 5 mM CaCl2, 1 mM Magnesium Acetate.
23°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Does not bind to hMMP-2 or -7.
See also the truncated and modified aptamer, FB3omf.
Human Matrix Metalloprotease 9 (hMMP-9) (F3) (ID# 377)
5'rGprGpfUp fUprApfCp fCprAprGp fCpfCpfUp fUpfCprAp fCpfUprGp fCpfUpfCp fCpfCprGp rGprApfCp rGpfCprGp fUpfCpfUp rGpfUprAp fUpfCpfCp rGpfCpfUp rApfCpfCp fCprGpfCp fCprGpfCp rApfCpfCp rApfCprGp rGpfUpfCp rGprGpfUp fCprApfCp rApfCp3'
75
21667.8 g/mole
615600 L/(mole·cm)
66.18%
1.62
35.20
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
S Gomes et al. A 99mTc-MAG3-aptamer for imaging human tumours associated with high level of matrix metalloproteinase-9. Bioconjugate Chem. (2012). Accepted for print. DOI: 10.1021/bc300146c.
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