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Apta-Index™: Tumor necrosis factor-alpha (TNFa) (VR11) (ID# 376)

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Tumor necrosis factor-alpha (TNFa) (VR11) (ID# 376)

Tumor necrosis factor-alpha (TNFa) (VR11)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Tumor necrosis factor-alpha (TNFa) Protein 7.0 nM (reported value) Selection Buffer: PBS, 0.005% (v/v) Tween-20. N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. This aptamer blocked TNFa signaling in a NF-?B luciferase reporter assays and also prevented TNFa-induced apoptosis and reduced NO production in cultured cells.
5'- dTpdGpdGpdTpdGpdGpdApdTpdGpdGp dCpdGpdCpdApdGpdTpdCpdGpdGpdCp dGpdApdCpdApdAp-3'
25 7788.10 g/mole 244400.00 L/(mole·cm) 64.00% 4.09 31.87

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

E Orava et al. A short DNA aptamer that recognizes TNFa and blocks its activity in vitro. ACS Chem. Biol. (2012) Accepted for print. DOI: 10.1021/cb3003557.

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