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Apta-Index™: HIV-1 R5 SU Glycoprotein gp120 (B40) (ID# 365)

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HIV-1 R5 SU Glycoprotein gp120 (B40) (ID# 365)

HIV-1 R5 SU Glycoprotein gp120 (B40)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA HIV-1 R5 gp120 Protein 21 nM (reported value) cHBS buffer: 10 mM HEPES, pH 7.4, 150 mM NaCl, 1 mM CaCl 2, 1 mM MgCl2, 2.7 mM KCl N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. IC= ~2nM in HIV-1Ba-L
5'-rGprGprGprAprGprApfCprAprAprGp rApfCpfUprAprGprApfCprGpfCpfUp fCprAprApfUprGpfUprGprGprGpfCp fCprApfCprGpfCpfCpfCprGprApfUp fUpfUpfUprApfCprGpfCpfUpfUpfUp fUprApfCpfCpfCprGpfCprApfCprGp fCprGprApfUpfUprGprGpfUpfUpfUp rGpfUpfUpfUpfUpfCprGprApfCprAp fUprGprAprGprApfCpfUpfCprApfCp rAprApfCprAprGpfUpfUpfCpfCpfCp fUpfUpfUprAprGpfUprGprAprGprGp rGpfUpfUprAprApfUpfUp -3'
117 37608.12 g/mole 1150000.00 L/(mole·cm) 48.72% 0.87 32.70

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

A. K. Dey et. al. Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1. RNA 11:873-884

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