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Apta-Index™: 4-1BB ligand (M12-23) (ID# 358)

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4-1BB ligand (M12-23) (ID# 358)

4-1BB ligand (M12-23)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA 4-1BB ligand on CD8+ T Cells Protein 40 nM (reported value) Low Salt Binding Buffer: 20 mM Hepes, pH 7.4; 50 mM NaCl; 2 mM CaCl2 ;0.01% BSA. N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. The authors constructed a bivalent version of the aptamer capable of constimulating CD8+ in vitro.
5'-rGprGprGp rAprGprAp rGprAprGp rGprAprAp rGprAprGp rGprGprAp fUprGprGp rGpfCprGprAp fCpfCprGp rAprApfCp rGpfUprGp fCpfCpfCp fUpfUpfCp rAprAprAp rGpfCpfCp rGpfUpfUp fCprApfCp fUprAprAp fCpfCprAp rGpfUprGp rGp fCprApfUp rAprApfCp fCpfCprAp rGprAprGp rGpfUpfCp rGprApfUp rAprGpfUp rApfCpfUp rGprGprAp fUpfCpfCp fCpfCpfCp fCp -3'
96 31154.72 g/mole 952100.00 L/(mole·cm) 58.33% 1.05 32.72

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

J. O. McNamara II et al.. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J. Clin. Invest. 118(2008):376-386.

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