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Apta-Index™: Anti-EGFR (E03) (ID# 357)

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Anti-EGFR (E03) (ID# 357)

Anti-EGFR (E03)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA mEGFR and hEGFR Protein 29 nM (reported value) 1X DPBS, 5mM MgCl2, pH 7.1-7.5 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Kd value listed is for mEGFR. The Kd value of this aptamer for hEGFR is 3.0 nM. See also Anti-EGFR E07.
5'- rGprGpfCprGpfCpfUpfCpfCprGprAp fCpfCpfUpfUprAprGpfUpfCpfUpfCp fUprGpfUprGpfCpfUprAprGpfUprAp fUprApfUpfCprGpfCprApfCprGprGp rApfUpfUpfUprAprApfUpfCprGpfCpfCprGpfUprAprGprAprAprAprAprGp fCprApfUprGpfUpfCprAprAprAprGp fCpfCprGprGprAprApfCpfCprGpfUp rGpfUprAprGpfCprApfCprAprGpfCp rAprGprAp-3'
93 29988.85 g/mole 921300.00 L/(mole·cm) 51.61% 1.09 32.55

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

N. Li et al. "Inhibition of Cell Proliferation by an Anti-EGFR Aptamer." PLoS One 6(2011): e20299.

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