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Apta-Index™: Carcinoembryonic Antigen Aptamer (YJ-1) (ID# 330)

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Carcinoembryonic Antigen Aptamer (YJ-1) (ID# 330)

Carcinoembryonic Antigen Aptamer (YJ-1)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Chimeric Carcinoembryonic Antigen (CEA) Protein 0.77 nM (reported value) 30 mM Tris-HCL, 150 mM NaCK, 1.5 mM MgCl2, 2 mM dithiothreitol, 1% bovine serum albumin, pH 7.5 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
5'-rGpfCprGprGprAprAprGpfCprGpfUprGpfCpfUprGprGprGpfCpfUprAprGprAprApfUprAprApfUprAprApfUprAprAprGprAprAprAprApfCpfCprAprGpfUprApfCpfUpfUpfUpfCprGpfUp-3'
49 15869.54 g/mole 507000.00 L/(mole·cm) 42.86% 1.97 31.30

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

YJ Lee et al. An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology 143(2012): 155-165.

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