Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
hEGFR and mEGFR
Protein
2.4 nM (reported value)
1X DPBS, 5mM MgCl2, pH 7.1-7.5
25°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Kd value listed is for hEGFR. The Kd value of this aptamer for mEGFR is 36 nM. See also Anti-EGFR E03.
Anti-EGFR (E07) (ID# 328)
5'rGprGpfCprGpfCpfUpfCpfCprGprApfCpfCpfUpfUprAprGpfUpfCpfUpfCpfUprGpfUprGpfCpfCprGpfCpfUprApfUprAprApfUprGpfCprApfCprGprGprApfUpfUpfUprAprApfUpfCprGpfCpfCprGpfUprAprGprAprAprAprAprGpfCprApfUprGpfUpfCprAprAprAprGpfCpfCprGprGprAprApfCpfCprGpfUprGpfUprAprGpfCprApfCprAprGpfCprAprGprAp3'
93
29987.87 g/mole
915000 L/(mole·cm)
52.69%
1.09
32.77
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
N. Li et al. "Inhibition of Cell Proliferation by an Anti-EGFR Aptamer." PLoS One 6(2011): e20299.
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