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Apta-Index™: GRK2 (C13.28) (ID# 314)

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GRK2 (C13.28) (ID# 314)

GRK2 (C13.28)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA G protein-coupled receptor kinase 2 Protein 1.2 nM (reported value) Binding Buffer 20 mM Tris (pH 7.0), 50 mM NaCl, 5 mM MgCl2,2 mM DTT, and 0.1% Lubrol (without nonspecific RNA) N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Activity IC50 - 11 nM Binding IC50 - 1.5 nM
5'-rGprGprCprAprGprAprCprCprAprUprAprCprGprGprGprAprGprAprGprAprAprAprCprUprUprGprCprCp-3'
28 9062.59 g/mole 282300.00 L/(mole·cm) 57.14% 3.54 32.10

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Tesmer et al., Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer, Structure (2012), doi:10.1016/j.str.2012.05.002

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