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Apta-Index™: HER-2 (S6) (ID# 284)

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HER-2 (S6) (ID# 284)

HER-2 (S6)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA HER-2 (SK-BR-3 cell line) Cells 94.6 nM (reported value) Binding buffer: 4.5 g/L glucose, 5 mM MgCl2, 0.1 mg/mL yeast tRNA, 1 mg/mL BSA in Dulbecco’s PBS.
Washing buffer: 4.5 g/L glucose, 5 mM MgCl2 in Dulbecco’s PBS
N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
5'-rGprGprGprAprGprAprUprAprCprCprAprGprCprUprUprAprUprUprCprAprAprUprUprUprGprGprAprUprGprGprGprGprAprGprAprUprCprCprGprUprUprGprAprGprUprAprAprGprCprGprGprGprCprGprUprGprUprCprUprCprUprCprUprGprCprCprGprCprCprUprUprGprCprUprAprUprGprGprGprGprAprGprAprUprAprGprUprAprAprGprUprGprCprAprAprUprCprUp-3'
98 31658.00 g/mole 976700.00 L/(mole·cm) 51.02% 1.02 32.41

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Kang, H. (2009). Isolation of RNA aptamers targeting Her-2-overexpressing breast cancer cells using cell-selex. Bull. Korean Chem. Soc., 30(8), 182-1831.

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