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Apta-Index™: Anti -?1-Adrenergic Receptor-Autoantibodies (Aptamer 110) (ID# 274)

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Anti -?1-Adrenergic Receptor-Autoantibodies (Aptamer 110) (ID# 274)

Anti -?1-Adrenergic Receptor-Autoantibodies (Aptamer 110)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA ?1-Adrenoceptor Autoantibodies(AABs) Protein n/a nM (reported value) Buffer 1: Tris buffer pH 7.3, 0.1% Tween-20, DMEM, 0.1% Tween-20 Buffer 2: Phosphate buffer pH 7.5, 0.1% Tween-20 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Low affinity aptamers were removed from the column using both buffers.
5'-dApdCpdApdGpdTpdApdApdCpdCpdGpdCpdGpdTpdGpdApdGpdGpdTpdCpdGpdAp-3'
21 6480.27 g/mole 212600.00 L/(mole·cm) 57.14% 4.70 30.48

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Haberland, A., et al. "Aptamer Neutralization of Beta1-Adrenoceptor Autoantibodies Isolated From Patients With Cardiomyopathies." Circulation Research, 109 (2011): 986-992.

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