Aptamer Details

Histone H3R8Me2sym (Clone 1) (ID# 224)

Aptamer Chemistry: RNA Target: Histone H3R8Me2sym Antigen/Target Category: Peptide Affinity (Kd): 12 nM (reported value) Binding Conditions/Buffer: N/A Binding Temp: N/A°C Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Comments: Truncated versions of the aptamer were investigated, but exhibited lower affinities for the target.

Sequence (): 5'rGprGprGprAprCprGprCprGprUprGprGprUprAprCprCprGprAprUprGprGprGprUprCprAprGprCprAprUprGprUprAprGprCprCprAprGprGprCprAprGprGprGprCprCprGprUprGprUprGprAprGprCprUprUprGprUprGprCprUprGprAprUprGprUprGprAprGprCprUprUprCprCprGprCprGprGprGprGprAprUprCp3' Length: 81 Molecular Weight: 26323.83 g/mole Extinction Coefficient: 784200 L/(mole·cm) GC Content: 64.20% nmoles/OD₂₆₀: 1.28 μg/OD₂₆₀: 33.57

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Hyun et al. "An RNA Aptamer That Selectively Recognizes Symmetric Dimethylation of Arginine 8 in the Histone H3 N-Terminal Peptide." Nucleic Acid Therapeutics, 21 (2011): 157-163.

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Aptamer Details

Histone H3R8Me2sym (Clone 1) (ID# 224)

Hyun et al. "An RNA Aptamer That Selectively Recognizes Symmetric Dimethylation of Arginine 8 in the Histone H3 N-Terminal Peptide." Nucleic Acid Therapeutics, 21 (2011): 157-163.

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