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Apta-Index™: P-Selectin (PF377) (ID# 223)

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P-Selectin (PF377) (ID# 223)

P-Selectin (PF377)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA P-Selectin Protein N/A nM (reported value) Washed with PBS and 0.9 mM CaCl2, 0.5 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4, 135 mM NaCl, and 8 mM Na2. N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Also see aVß3 Clone 17.16 , which prevents the binding of sickle cell RBCs to HUVECs.
5'-rApfCprGpfCpfUpfCprAprApfCprGprAprGpfCpfCprAprGprGprAprApfCprApfUpfCprGprApfCprGpfUpfCprAprGpfCprAprAprApfCprGpfCprGprAprGpfCprGpfCprAprApfCpfCprAprGpfUprAprApfCprApfCpfCp-3'
57 18386.21 g/mole 559700.00 L/(mole·cm) 57.89% 1.79 32.85

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Burnette et al. "RNA Aptamer Therapy for Vaso-Occlusion in Sickle Cell Disease." Nucleic Acids Therapeutics, 21(2011): 275-283. Jenison et al. "Oligonucleotide Inhibitors of P-Selectin Dependent Neutrophil-Platelet Adhesion." Antisense & Nucleic Acid Development, 8(1998): 265-279.

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