Aptagen, LLC
RNA
Theophylline
Small Organic
100 nM (reported value)
Buffer A (100 mM Hepes (pH 7.3), 5 mM MgCI2, and 0.5 M NaCI)
N/A°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Truncated version from Figure 2 in paper. Arrows indicate truncation. Binds to theophylline with 10,000 times greater affinity than caffeine, which differs only by a methyl group.
Theophylline (mTCT8-4) (ID# 150)
5'rAprGprUprGprAprUprAprCprCprAprGprCprAprUprCprGprUprCprUprUprGprAprUprGprCprCprCprUprUprGprGprCprAprGprCprAprCprUp3'
38
12097.29 g/mole
364600 L/(mole·cm)
52.63%
2.74
33.18
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Jenison et al. "High-resolution molecular discrimination by RNA." Science, 263(1994): 1425-1429.
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