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Apta-Index™: Theophylline (mTCT8-4) (ID# 150)

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Theophylline (mTCT8-4) (ID# 150)

Theophylline (mTCT8-4)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA Theophylline Small Organic 100 nM (reported value) Buffer A (100 mM Hepes (pH 7.3), 5 mM MgCI2, and 0.5 M NaCI) N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Truncated version from Figure 2 in paper. Arrows indicate truncation. Binds to theophylline with 10,000 times greater affinity than caffeine, which differs only by a methyl group.
5'-rAprGprUprGprAprUprAprCprCprAprGprCprAprUprCprGprUprCprUprUprGprAprUprGprCprCprCprUprUprGprGprCprAprGprCprAprCprUp-3'
38 12097.29 g/mole 364600.00 L/(mole·cm) 52.63% 2.74 33.18

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Jenison et al. "High-resolution molecular discrimination by RNA." Science, 263(1994): 1425-1429.

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