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Apta-Index™: ERK 1/ ERK2 (Family II) (ID# 143)

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ERK 1/ ERK2 (Family II) (ID# 143)

ERK 1/ ERK2 (Family II)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA Extracellular Regulated Kinase 1 and 2 (ERK 1 and ERK2) Protein 4.7 nM (reported value) Buffer: 10 mM HEPES, pH 7.5; 10 mM MgCl2 Denatured in water at 95°C for 3 min and slowly cooling in binding buffer from 55°C to 30°C. Inhibits phosphorylation by ERK1/2 with a Ki = ~5.4 nM.

See also the truncated version below.
5'- rGprGprGprAprGprAprGprCprCprAp rUprAprCprCprUprGprAprCprAprAp rAprGprAprCprGprCprUprAprGprCp rGprAprAprUprUprGprGprUprUprCp rCprUprCprAprCprUprCprAprAprAp rAprGprUprAprGprGprGprGprAprAp rAprGprCprGprUprUprAprUprUprAp rAprGprAprAprAprCprCprAprAprAp rAprUprUprUprGprAprCprAprGprGp rUprUprAprCprGprCprAprUprCprCp rUprGprCprAprUprCprCprUprCp-3'
109 35091.26 g/mole 1100300.00 L/(mole·cm) 45.87% 0.91 31.89

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Seiwert, S., et al. "RNA aptamers as pathway-specific MAP kinase inhibitors." Chemistry & Biology, 7(2000): 833-834.

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