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Apta-Index™: Basic Fibroblast Growth Factor (26A-t) (ID# 136)

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Basic Fibroblast Growth Factor (26A-t) (ID# 136)

Basic Fibroblast Growth Factor (26A-t)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA Basic Fibroblast Growth Factor (bFGF) Protein 190 pM (reported value) Selection Buffer (1X PBS = 10.1 mM Na2HPO4/1.8 mMKH2PO4/137 mM NaCl/2.7 mM KCl, pH 7.4) N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Heat-denatured bFGF (90C for 15 min) binds to aptamer with Kd > 1uM. This is a biphasic binding with Kd 0.19+-0.02 nM.
5'-rGprGprUprGprAprAprGprGprCprAprAprCprGprUprAprUprAprGprGprCprAprAprGprCprAprCprAprCprUprUprCprAprCprCp-3'
34 10943.71 g/mole 340500.00 L/(mole·cm) 52.94% 2.94 32.14

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Jellinek, D., et al. "High-affinity RNA ligands to basic fibroblast growth factor inhibit receptor binding." Proceedings of the National Academy of Sciences of the United States of America, 90(1993): 11227–11231.

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