Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
HIV-1 R5 SU Glycoprotein
Protein
5 nM (reported value)
HBS Buffer (10 mM HEPES (pH 7.4), 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2, 2.7 mM KCl)
N/A°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
HIV-1 R5 Glycoprotein gp120 (B4) (ID# 125)
5'rAprApfUpfUprAprApfCpfCpfCpfUpfCprApfCpfUprAprAprAprGprGprGprAprApfCpfUprGpfUpfUprGpfUprGprAprGpfUpfCpfUpfCprApfUprGpfUpfCprGprAprAprGprAprGpfCprGprGpfUpfUprAprAprGprGprGprAprGprApfUpfUpfUprAprGprGpfCprAprGpfCprAprGpfCpfUpfUprGprGprApfCprAprGpfUprGpfUprApfUpfCprGprGpfCpfUprGprAprGpfUpfUprGprAprGpfCprGpfUpfCpfUprAprGpfUpfCpfUpfUprGpfUpfCpfUp3'
114
36897.78 g/mole
1148700 L/(mole·cm)
47.37%
0.87
32.12
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Khati, M., et al. "Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2'F-RNA Aptamers." Journal of Virology, 77(2003): 12692-12698.
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