Forget Antibodies. Use Aptamers!™ Forget Antibodies. Use Aptamers!™
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Aptamer Technologies

  • Apta-beacons &
    Apta-sensors

  • Peptimers™
    (Apta-peptides)

  • Aptabodies™
    (NextGEN Aptamers)

No Capturing. No Washing. Just READ....In Minutes!

Aptagen’s "No Capturing. No Washing. Just READ" assay is a radical advancement in diagnostic technology. Aptagen, LLC has developed a sensitive diagnostic platform that can detect virtually any target or antigen (from small molecules to protein biomarkers and cells) in a variety of sample matrices. Unlike current diagnostic formats, such as the traditional ELISA method and the more recently popular Luminex® approach, Aptagen’s Apta-Beacon™ assay eliminates the need for multiple target manipulation steps. The Apta-Beacon™ platform requires neither capturing nor washing of sample(s), streamlining the analysis to quickly provide results with higher sensitivity.


What are Apta-Beacons™?

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Apta-beacons™A novel (one-step) approach to detect analytes in virtually any sample type (such as serum). Aptagen's engineering capabilities include: allosteric ribozymes, molecular switches, and molecular beacons.

AptaBeacon Flyer ah062016.pdf (3.1 MB)


Advantages:
  1. Large dynamic range of sensitivity.
  2. Binding to target analyte produces an output signal (fluorescent or colorimetric)
  3. No need for the cumbersome multi-step approach of ELISA assays.

What are Peptimers™?


Peptimers™ are peptide-based aptamers: high affinity ligands composed of amino acid building blocks instead of the nucleic acid bases that make up RNA or DNA aptamers.  Peptimers™ are another option offered by Aptagen to continually ‘Advance Aptamer Applications’.  Unlike peptides or single-chain antibodies generated by the phage display or biopanning process, peptimers™ are discovered through a process similar to aptamer SELEX, called mRNA display. 

Contact Us for more information on how peptimers™ may meet your application needs.

Peptimer Flyer aps042717.pdf (768.7 KB)

WHAT IS AN APTABODY™?

An aptabody™ is a supramolecular form of an aptamer ligand containing a wide variety of functional groups. The aptamer component acts as a scaffold to hold into place one or more functional groups such as amino acids, fatty acids, carbohydrates, small molecules and/or metals in a unique orientation in 3-D space. The order and proximity of these functional groups play a role in enhanced functionalities ranging from higher affinity and specificity over “naked” aptamers, to enzyme biomimetics, improved molecular targeting in vivo, cellular trafficking, pharmacokinetics/dynamics, and drug-like properties.

What are Aptabodies™?

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Aptamers are best leveraged as research reagents or as diagnostic elements in biosensor platforms.  Aptamers are not mature enough for therapeutics; however, they can be used for targeting, as the vehicle to deliver a drug payload.  To overcome the limitations of aptamers as drug candidates, Aptagen has conceptualized the Aptabody™ for the therapeutic area.

It's not an antibody. It's not an aptamer.
It's an "aptabody".

Advancing Aptabody Applications

Aptabody Flyer. PDF (277KB)


What is an aptabody™?
 An aptabody™ is a supramolecular form of an aptamer ligand containing a wide variety of functional groups. The aptamer component acts as a scaffold to hold into place one or more functional groups such as amino acids, fatty acids, carbohydrates, small molecules and/or metals into a unique orientation in 3-D space. The order and proximity of these functional groups play a role in enhanced functionalities ranging from higher affinity and specificity over “naked” aptamers, to enzyme biomimetics, improved molecular targeting in vivo, cellular trafficking, pharmacokinetics/dynamics, and drug-like properties.

NOTE: Conventional antibodies have a chemical alphabet of the naturally occurring amino acids.  Aptabodies™, by definition, have a chemical alphabet of all amino acids, fatty acids, sugars, as well as synthetic compounds, co-factors, metal ions, etc...

Can aptabodies represent a class of artificial enzymes, biomaterials, and nanomaterials? Contact Us.

Can aptabodies represent a class of artificial enzymes, biometrics, and nanomaterials? Contact Us.


Serving over 50 Companies, Organizations, and Universities globally.

Bio Rad Biogen Idec Cephalon Covidien GE Genetech Harvard IBM Md. Anderson Cancer Center Medimmune Merck Nestle Penn State
Forget Antibodies. Use Aptamers!™ Forget Antibodies. Use Aptamers!™