Aptagen, LLC
DNA
Sialyllactose
Other
4.9 µM (reported value)
Binding Buffer (50 mM Tris-HCl (pH 7.6), 250 mM NaCl, 5 mM MgCl2)
RT°C
Denatured at 95°C for 5 min and cool at RT for 30 min.
Except for the primer 1 region, thymidines contained an amino linker with terminal amine at the C5 position. This was an attempt to offset the repulsive force between the negatively-charged target and DNA backbone.
Sialyllactose (Sl-11) (ID# 90)
5'dGpdTpdApdCpdGpdApdApdTpdTpdCpdApdCpdGpdApdGpdGpdTpdTpdGpdCpdCpdApdGpdCpdGpdGpdGpdGpdCpdCpdApdGpdCpdCpdApdCpdTpdTpdCpdTpdGpdTpdCpdApdGpdTpdGpdApdApdTpdTpdCpdCpdTpdGpdCpdTpdCpdGpdTpdApdTpdApdTpdCpdTpdApdCpdTpdCpdGpdCpdCpdCpdGpdCpdCpdTpdGpdCpdGpdApdGpdCpdApdTpdGpdGpdApdGpdTpdCpdGpdGpdApdTpdCpdCpdTpdCpdTpdAp3'
102
31347.28 g/mole
947500 L/(mole·cm)
56.86%
1.06
33.08
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Masud, M, et al. "Sialyllactose-binding modified DNA aptamer bearing additional functionality by SELEX." Bioorganic & Medicinal Chemistry, 12 (2004): 1111-1120.
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