Aptagen, LLC
DNA
Tfr (transferrin receptor) / EpCAM (epithelial cell adhesion molecule)
Small Organic
Tfr: 110 ± 22.0, EpCAM: 85.6 ± 28.5 nM (reported value)
0.1 M sodium acetate (CH3COONa), 0.05 M sodium chloride (NaCl), and 5 mM MgCl2
37°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Bifunctional aptamer
TEPP (ID# 7232)
5'dGpdCpdGpdCpdGpdGpdTpdApdCpdCpdGpdCpdGpdCpdTpdApdApdCpdGpdGpdApdGpdGpdTpdTpdGpdCpdGpdTpdCpdCpdGpdTp3'
33
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Macdonald, J., Denoyer, D., Henri, J., Jamieson, A., Burvenich, I. J. G., Pouliot, N., and S. Shigar. 2020. Bifunctional Aptamer–Doxorubicin Conjugate Crosses the Blood–Brain Barrier and Selectively Delivers Its Payload to EpCAM-Positive Tumor Cells. Nucleic Acid Therapeutics 30:2: 117-128. DOI: 10.1089/nat.2019.0807
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