Aptamer Details

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Apta 3 (ID# 7180)

Aptamer Chemistry: DNA Target: Carcinoembryonic antigen (CEA) Antigen/Target Category: Protein Affinity (Kd): 60.4 nM (reported value) Binding Conditions/Buffer: Not given. Binding Temp: 37°C Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Specificity: Apta 3 displayed high specificity and affinity for T84 cells (human carcinoma cell line derived from a lung metastasis of a colon carcinoma). Comments:

Sequence (): 5’dTpdCpdGpdCpdGpdCpdGpdApdGpdTpdCpdGpdTpdCpdTpdGpdGpdGpdGpdGpdGpdGpdTpdGpdTpdApdTpdCpdGpdTpdTpdGpdApdCpdGpdApdGpdTpdTpdGpdCpdGpdCpdGpdTpdGpdCpdGpdTpdCpdTpdCpdGpdTpdGpdCpdCpdGpdCpdApdTpdCpdGpdTpdCpdCpdTpdCpdCpdCp3’ Length: 70 Molecular Weight: 21611.9 g/mole Extinction Coefficient: 631300 L/(mole·cm) GC Content: 67.14% nmoles/OD₂₆₀: 1.58 μg/OD₂₆₀: 34.23

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Melo, M.; Correa, C.; Cunha, P.; Goes, A.; Gomes, D.; Andrade, A. DNA aptamers selection for carcinoembryonic antigen (CEA). Bioorg. Med. Chem. Lett. 2020 May 23; 30(15): 127278. DOI: 10.1016/j.bmcl.2020.127278

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Aptamer Details

Apta 3 (ID# 7180)

Melo, M.; Correa, C.; Cunha, P.; Goes, A.; Gomes, D.; Andrade, A. DNA aptamers selection for carcinoembryonic antigen (CEA). Bioorg. Med. Chem. Lett. 2020 May 23; 30(15): 127278. DOI: 10.1016/j.bmcl.2020.127278

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