Aptamer Details

1-F (ID# 636)

Aptamer Chemistry: DNA Target: CD117 Antigen/Target Category: Protein Affinity (Kd): 4.24 nM (reported value) Binding Conditions/Buffer: 1X DPBS Binding Temp: 23°C Refolding Protocol: no-refolding Specificity: No binding detected by flow cytometry against cell lines: U937, CA46, 468, LNCAP. No binding detected by fluorescence microscopy against U937. Comments:

Sequence (): 5'dGpdApdGpdGpdCpdApdTpdApdCpdCpdApdGpdCpdTpdTpdApdTpdTpdApdTpdTpdGpdGpdGpdGpdCpdCpdGpdGpdGpdGpdCpdApdApdGpdGpdGpdGpdGpdGpdGpdGpdTpdApdCpdCpdGpdTpdGpdGpdTpdApdGpdGpdApdCpdApdGpdApdTpdApdGpdTpdApdApdGpdTpdGpdCpdApdApdTpdCpdTpdGpdCpdGpdApdAp3' Length: 79

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Zhao, N, Pei, S-N, Qi, J, Zeng, Z, Iyer, SP, Lin, P, et al. (2015). Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia. Biomaterials 67: 42-51

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Aptamer Details

1-F (ID# 636)

Zhao, N, Pei, S-N, Qi, J, Zeng, Z, Iyer, SP, Lin, P, et al. (2015). Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia. Biomaterials 67: 42-51

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