Aptagen, LLC
RNA
HER3
Protein
45 nM (reported value)
Binding buffer: 10 mM HEPES (pH 7.4), 100 mM NaCl, and 2.5 mM MgCl2
37°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
HER3 (A30) (ID# 62)
5'rGprAprAprUprUprCprCprGprCprGprUprGprUprGprCprCprAprGprCprGprAprAprAprGprUprUprGprCprGprUprAprUprGprGprGprUprCprAprCprAprUprCprGprCprAprGprGprCprAprCprAprUprGprUprCprAprUprCprUprGprGprGprCprGprGprUprCprCprGprUprUprCprGprGprGprAprUprCprCp3'
79
25442.28 g/mole
761100 L/(mole·cm)
59.49%
1.31
33.43
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Chi-Hong et al. "Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3." Proceedings of the National Academy of Sciences of the United States of America 100,(2003):9226-9231.
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