Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-NH2-RNA
Insulin Receptor Antibody (MA20)
Antibody
30 nM (reported value)
Binding buffer: 30 mM Tris-HCl (pH 7.5), 150 mM NaC1, 10 mM MgC12, 2 mM dithiothreitol, and 1.0% BSA
RT°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Insulin Receptor Antibody (MA20) (#1) (ID# 57)
5'rGprGprGprAprGprAprGpnCprGprGprAprAprGpnCprGpnUprGpnCpnUprGprGprGpnCpnCpnUprGprGpnUpnUprGpnCpnUprGpnUprAprAprAprAprApnUprAprGprApnCprApnCprGprAprApnUpnCpnUprGpnCpnCprGprApnCpnCprApnUprAprApnCpnCpnCprAprGprAprGprGpnUpnCprGprApnUprGprGprApnUpnCpnCpnCpnCpnCpnCp3'
86
50020.06 g/mole
843600 L/(mole·cm)
58.14%
1.19
59.29
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Lee, Seong-Wook and Sullenger, Bruce A. "Isolation of a Nuclease-resistant Decoy RNA That Selectively Blocks Autoantibody Binding to Insulin Receptors on Human Lymphocytes." Journal of Experimental Medicine, 184 (1996): 315-324.
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