Aptamer Details

GL21.T (ID# 552)

Aptamer Chemistry: RNA Target: Axl tyrosine kinase receptor Antigen/Target Category: Protein Affinity (Kd): 12 nM (reported value) Binding Conditions/Buffer: Dulbecco's Modified Eagle's Medium (DMEM), 10% FBS, 2mM L-glutamine Binding Temp: 37°C Refolding Protocol: 85C for 5 minutes, snap cooled on ice for 2 minutes, and then warmed up to 37C. Comments: Note that the sequence is 2'-fluoropyrimidine, 2'-ribopurine (see reference paper).

Sequence (): 5'rApfUprGprApfUpfCprAprApfUpfCprGpfCpfCpfUpfCprAprApfUpfUpfCprGprApfCprAprGprGprAprGprGpfCpfUpfCprApfCp3' Length: 34 Molecular Weight: 10875.53 g/mole Extinction Coefficient: 335000 L/(mole·cm) GC Content: 50.00% nmoles/OD₂₆₀: 2.99 μg/OD₂₆₀: 32.46

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Laura Cerchia, Carla L Esposito, Simona Camorani, Anna Rienzo, Loredana Stasio, Luigi Insabato, Andrea Affuso and Vittorio de Franciscis,"Targeting Axl With an High-affinity Inhibitory Aptamer". Molecular Therapy vol.20 no.12, 2291-2303, Dec2012.

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Aptamer Details

GL21.T (ID# 552)

Laura Cerchia, Carla L Esposito, Simona Camorani, Anna Rienzo, Loredana Stasio, Luigi Insabato, Andrea Affuso and Vittorio de Franciscis,"Targeting Axl With an High-affinity Inhibitory Aptamer". Molecular Therapy vol.20 no.12, 2291-2303, Dec2012.

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