Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
Brain capillary endothelia and parenchyma
Tissue
N/A nM (reported value)
SELEX selection buffer: 10 mM HEPES (pH 7.4), 50 mM NaCl, 1 mM MgCl2, 1 mM CaCl2, 0.01% bovine serum albumin.
Selection was conducted in situ in mice. 37°C Denatured at 94°C for 3 min then slowly cooled to room temperature. This aptamer was generated from in vivo SELEX and was shown to enter brain endothelial cells in vitro and brain parenchyma in vivo.
Brain Penetrating Aptamer (A15) (ID# 475)
Selection was conducted in situ in mice. 37°C Denatured at 94°C for 3 min then slowly cooled to room temperature. This aptamer was generated from in vivo SELEX and was shown to enter brain endothelial cells in vitro and brain parenchyma in vivo.
5'rGprGprGprAprGprGprApfCprGprApfUprGpfCprGprGpfCprGpfUprApfUpfUprGpfCprGpfCprGprAprGprGprApfUpfUprApfUpfCpfCprGpfCpfUpfCprApfUpfCprGpfUpfUprGpfUpfUprGp fUpfUprGpfUprGpfCprAprGprApfCprGprApfCpfUpfCprGpfCpfCpfCprGprAp 3'
72
22979.59 g/mole
690300 L/(mole·cm)
59.15%
1.45
33.29
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Cheng C, B Davidson, et al. (2013) In vivo SELEX for identification of brain-penetrating aptamers. Molecular Therapy - Nucleic Acids 2: e67.
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