Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Peptide
CCR5
Protein
N/A nM (reported value)
RPMI-10 medium
37°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Decreased induction of R5-tropic reporter virus by 95%. Did not affect CD4 or CXCR4 expression.
HIV co-receptor CCR5 (BY6M4) (ID# 461)
5'MetAlaTyrProTyrAspValProAspTyrAlaAspLeuProAsnLeuTrpPheIleIleIlePheLeuArgLeuValValLeuPheLeuLeuPheValIleValLeuIleArgAlaSerValLeuTyrTrp3'
44
6018.13 g/mole
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Scheideman EH, DiMaio D, et al. (2012) Transmembrane protein aptamers that inhibit CCR5 expression and HIV coreceptor function. J. Virol. 86: 10281-10292.
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