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Apta-Index™: Human Immunoglobulin G (IgG) (Apt 8-2) (ID# 375)

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Human Immunoglobulin G (IgG) (Apt 8-2) (ID# 375)

Human Immunoglobulin G (IgG) (Apt 8-2)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Chimeric hlgG-Fc Protein 90.9 nM (reported value) Binding Buffer (145mM NaCl, 5.4 mM KCl, 0.8mM MgCl, 1.8 mM CaCl, and 20 mM Tris-HCl (pH 7.6)) NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. This aptamer binds to the Fc domain of hIgG.
In picture of aptamer, lowercase letters are deoxynucleotide residues and uppercase letters are ribonucleotide or 2'-F-ribonucleotide residues.
5'dGpdGprAprGprGpfUprGpdCpfUpdCpdCpdGpdApdApdAprGprGpdApdApfCpfUpdCpdCp3' 23 7224.54 g/mole 226000 L/(mole·cm) 60.87% 4.42 31.97

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.

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