Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
Human complement C5 component (C5a)
Protein
100 nM (reported value)
Binding Buffer: Phosphate-buffered saline with 1 mM MgCl2. Incubated in the presence or absence of trypsin (between 0.3 and 0.0001 μg/ml)
37°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
C5a (C5C6) (ID# 352)
5'fCprGprApfUprGpfCprGprGpfUpfCp fUpfCprApfUprGpfCprGpfUpfCprGp rAprGpfUprGpfUprGprAprGpfUpfUp fUprApfCpfCpfUpfUpfCprGp 3'
39
12189.15 g/mole
365900 L/(mole·cm)
55.26%
2.73
33.31
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
G Biesecker et al.. "Derivation of RNA aptamer inhibitors of human complement C5." Immunopharmacology 42(1999):219-230
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