Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
Neurotrophin receptor, TrkB
Protein
2.1 nM (reported value)
DPBS Running Buffer: 0.901 mM CaCl2, 0.493 mM MgCl2, 2.67 mM KCl, 1.47 mM KH2PO4 , 137.93 mM NaCl and 8.06 mM Na2HPO4.
37°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
This aptamer is a TrkB agonist and was shown to increase the phosphorylation of TrkB and downstream signaling protein, Akt.
Neurotrophin receptor, TrkB (C4-3) (ID# 306)
5'rGprGprGprAprGprGprApfCprGprApfUprGpfCprGprGp fUpfCprGpfUprApfUpfUprApfUpfCpfCprGpfCpfUprGpfCprApfCprGpfCp fCprAprGprApfCprGprApfCpfUpfCprGpfCpfCpfCprGprAp3'
51
16478.87 g/mole
490000 L/(mole·cm)
64.71%
2.04
33.63
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Huang, Y. (2012). RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB. J. Pharmacol. Exp. Ther. 82(2012):623-635.
Have your aptamer oligo synthesized ORDER NOW
We are always looking for ways to improve. Please tell us what you think.